Biomonitoring of Lead Exposure in Children from Two Fishing Communities at Northern Colombia

Lead (Pb) exposure is a growing concern in developing countries, especially in vulnerable children. The objective of this study was to evaluate blood lead levels (BLL) in children from two fishing populations at Northern Colombia, Loma de Arena and Tierrabomba, as well as their association with morphometric parameters, markers of hematological status, liver function, and mRNA expression of genes related to Pb toxicity. A total of 198 blood samples were collected from participants aged 5-16 years old. The mean (+/- standard error) BLL for the studied sample was 3.6 +/- 0.3 mu g/dL, and the 97.5th percentile was 21.0 mu g/dL. The participants of Loma de Arena and Tierrabomba presented BLL of 3.9 +/- 0.5 and 2.9 +/- 0.3 mu g/dL, respectively. Children born preterm had greater BLL than those born at full term. Boys had greater BLL than girls, which also occurred for participants between 12 and 16 years old, compared with those aged 5-11 years old. The BLL were negatively correlated with body mass index in children from Loma de Arena, but an opposite behavior was observed for Tierrabomba. In Loma de Arena, the mRNA expression of interferon gamma, a pro-inflammatory cytokine, increased with the BLL, but that of delta-aminolevulinic acid dehydrogenase, a sensor for Pb poisoning, decreased. In Tierrabomba, gene expression did not change with BLL. These results show that in fishing communities, lead exposure promotes different health impacts depending on age, sex, and other site-specific factors. In any case, appropriate educational and intervention programs should be carried out to minimize Pb exposure in children.

Automated summary

The study evaluated blood lead levels in children from fishing populations in Northern Colombia and found that lead exposure promoted different health impacts depending on age, sex, and other site-specific factors. Boys had greater BLL than girls, and children born preterm had higher BLL levels. In Loma de Arena, the mRNA expression of interferon gamma increased with BLL, while it decreased in Tierrabomba. Appropriate educational and intervention programs should be carried out to minimize Pb exposure in children in fishing communities.