PoSeiDon: a Nextflow pipeline for the detection of evolutionary recombination events and positive selection

PoSeiDon is an easy-to-use pipeline that helps researchers to find recombination events and sites under positive selection in protein-coding sequences. By entering homologous sequences, PoSeiDon builds an alignment, estimates a best-fitting substitution model and performs a recombination analysis followed by the construction of all corresponding phylogenies. Finally, significantly positive selected sites are detected according to different models for the full alignment and possible recombination fragments. The results of PoSeiDon are summarized in a user-friendly HTML page providing all intermediate results and the graphical representation of recombination events and positively selected sites.

Automated summary

PoSeiDon is an easy-to-use pipeline that helps researchers find recombination events and sites under positive selection in protein-coding sequences. The tool builds an alignment, estimates a best-fitting substitution model, performs recombination analysis, and detects positively selected sites according to different models, with results summarized in a user-friendly HTML page.