期刊
BIOCHIP JOURNAL
卷 14, 期 2, 页码 137-147出版社
KOREAN BIOCHIP SOCIETY-KBCS
DOI: 10.1007/s13206-020-4201-8
关键词
Tumors; 3D Bioprinting; Microenvironment; Metastasis; Method
资金
- National Research Foundation (NRF) of Korea [2018R1A2B2002066, 2016M3A9B 4917320]
- Institute of Information & Communications Technology Planning & Evaluation (IITP) [2019-0-00047]
- Ministry of Science and ICT (MSIT) in Korea
- National Research Foundation of Korea [2018R1A2B2002066] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Tumors in vivo exist in a microenvironment, so-called tumor microenvironment (TME), which includes peripheral blood vessels, immune cells, fibroblasts, signalling molecules and extracellular matrix. In recent years, considerable efforts have been focused on developing bioprinting methods because 3D bioprinting can better recapitulate TMEs by accurately printing different types of TME cells in spatially localised regions. In this review, we first introduce TME and 3D bioprinting methods and later discuss bioprinted TMEs as tumor equivalents for understanding tumor biology as well as testing drug efficacy.
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