期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1867, 期 11, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2020.118817
关键词
Heme; Iron acquisition; Fungi; CFEM protein; Hemophore
资金
- Israel Science Foundation [487/15, 587/19]
- U.S-Israel Binational Science Foundation [2017228]
Iron acquisition is challenging in most environments. As an alternative to elemental iron, organisms can take up iron-protoporphyrin IX, or heme. Heme can be found in decaying organic matter and is particularly prevalent in animal hosts. Fungi have evolved at least three distinct endocytosis-mediated heme uptake systems, which have been studied in detail in the organisms Candida albicans, Cryptococcus neoformans and Schizosaccharomyces pombe. Here we summarize the known molecular details of these three uptake systems that enable parasitic and saprophytic fungi to take advantage of external heme as either cellular iron or heme sources.
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