期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1867, 期 7, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2020.118713
关键词
Cell proliferation; Cell growth; WD40 domains; MYC; Glia; Signal transduction
资金
- National Health and Medical Research Council [GNT1046032, GNT1162652]
- Australian Research Council [FT120100193]
- Cancer Council [GNT1101931]
- UQ International Scholarship from the University of Queensland
- Australian Research Council [FT120100193] Funding Source: Australian Research Council
WD40-Repeat Protein 62 (WDR62) is required to maintain neural and glial cell populations during embryonic brain growth. Although elevated expression of WDR62 is frequently associated with several tumour types, potential effects of excess WDR62 on proliferative growth remain undefined. Here, we demonstrate that glia specific overexpression of WDR62 in Drosophila larval brains resulted in increased cell size, over-proliferation and increased brain volume, without overt disruption of tissue organization. We further demonstrate WDR62 promoted over-proliferation and brain overgrowth by activating AURKA and pAKT signalling to increase MYC function in glial cells. Together these data suggest WDR62 normally functions in the glial lineage to activate oncogenic signalling networks, promoting proliferation and brain overgrowth.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据