期刊
BIOCHEMISTRY
卷 59, 期 28, 页码 2608-2615出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biochem.0c00309
关键词
-
资金
- National Institutes of Health [R01 AI088001]
- National Science Foundation [CHE-1903899]
The virus that causes COVID-19, SARS-CoV-2, has a large RNA genome that encodes numerous proteins that might be targets for antiviral drugs. Some of these proteins, such as the RNA-dependent RNA polymerase, helicase, and main protease, are well conserved between SARS-CoV-2 and the original SARS virus, but several others are not. This study examines one of the proteins encoded by SARS-CoV-2 that is most different, a macrodomain of nonstructural protein 3 (nsp3). Although 26% of the amino acids in this SARS-CoV-2 macrodomain differ from those observed in other coronaviruses, biochemical and structural data reveal that the protein retains the ability to bind ADP-ribose, which is an important characteristic of beta coronaviruses and a potential therapeutic target.
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