期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 526, 期 3, 页码 647-653出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2020.03.138
关键词
Non-neural surface ectodermal cells; Multicellular rosette formation; Convergent F-actin protrusions and cable network; Posterior neuropore (PNP); Grhl3-KO mice; Computational visual modeling
资金
- NIH [R01NS102261, R01DE026737, R01DE0221696]
- Shriners Hospitals for Children [86600, 85105]
The mechanisms underlying mammalian neural tube closure remain poorly understood. We report a unique cellular process involving multicellular rosette formation, convergent cellular protrusions, and Factin cable network of the non-neural surface ectodermal cells encircling the closure site of the posterior neuropore, which are demonstrated by scanning electron microscopy and genetic fate mapping analyses during mouse spinal neurulation. These unique cellular structures are severely disrupted in the surface ectodermal transcription factor Grhl3 mutants that exhibit fully penetrant spina bifida. We propose a novel model of mammalian neural tube closure driven by surface ectodermal dynamics, which is computationally visualized. (C) 2020 Elsevier Inc. All rights reserved.
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