期刊
ARCHIVES OF VIROLOGY
卷 165, 期 11, 页码 2453-2459出版社
SPRINGER WIEN
DOI: 10.1007/s00705-020-04714-3
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资金
- National Key R&D Program of China [2017YFD0501600]
- National Natural Science Foundation of China (NSFC) [31702275, 18246629G]
- Central Public-Interest Scientific Institution Basal Research Fund of Chinese Academy of Agricultural Sciences [1610342018017]
Canine parvovirus type 2 (CPV-2) is currently circulating in domestic and wild animals, but our knowledge about CPV-2 infections in raccoon dogs is limited. In this study, VP2 gene sequences of CPV-2 were amplified from rectal swabs of 14 diarrhetic raccoon dogs (Nyctereutes procyonoides) in Hebei province, China, in 2016 and 2017. Phylogenetic analysis of the VP2 gene sequences revealed that most of these sequences (11 of 14) belonged to the same subclade as raccoon dog strain CPV-2/Raccoon_Dog/China/DP-1/16 isolated from Shandong province in 2016. A comparison of deduced amino acid sequences revealed presence of the substitutions S297A and S27T in 11 of those 14 sequences. I418T was observed in a minority of the sequences (4 of 14). In addition, A300D and T301I, P13S and I219V, and N419K were found in three of the sequences. This study shows that CPV-2 strains with different substitutions in their VP2 amino acid sequences were spreading among raccoon dogs in Hebei during 2016 and 2017 and suggests that further studies are needed to monitor the distribution of these strains in China.
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