期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 43, 期 8, 页码 765-772出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-020-01258-7
关键词
Hydroxychloroquine; Chloroquine; COVID-19; SARS-CoV-2; Treatment
资金
- National Natural Science Foundation of China [81822016, 81771382]
A novel coronavirus, later named SARS-CoV-2, was first reported in China in December 2019 and subsequently widely identified in the United States, Japan, South Korea, France, India, and other countries. The disease caused by SARS-CoV-2 infection was called COVID-19. The high fatality and morbidity rates of COVID-19 make it the third largest global epidemic in this century. However, there are currently no approved antiviral drugs for the COVID-19 treatment. Recently, two old antimalarial drugs, hydroxychloroquine and chloroquine, have been found to exert anti-SARS-CoV-2 effects both in vitro and in vivo. Preliminary clinical evidence suggests these drugs may have an effect on the treatment of COVID-19. Herein, we review the pharmacokinetics characteristics and antiviral effects of these drugs, in addition to their side effects and clinical evidence of their use for the COVID-19 treatment.
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