期刊
ARCHIVES OF MICROBIOLOGY
卷 202, 期 8, 页码 2263-2268出版社
SPRINGER
DOI: 10.1007/s00203-020-01928-6
关键词
Salmonella; Drug-resistance; Virulence; ompF; invA; invE
类别
资金
- Beijing Science and Technology Commission-Beijing Science and Technology PlanCapital Food Quality and Safety Guarantee Project-Developmentand Demonstration of Whole Genome Sequencing Analysis and Rapid Detection Kit for Salmonella in Swine [Z181100009318007]
- Natural Science Foundation of Liaoning province [20170540207]
- National Key Research and Development Program of China [2018YFD0500505]
Salmonelladeveloped drug-resistance under durative antibiotic pressures pressure. The widespread prevalence ofSalmonellahas been associated with not only drug-resistance but also pathogenicity. Outer membrane porin proteins (OMPs) are critical for the drug resistance of bacteria. Virulence genes inSalmonellapathogenicity islands (SPIs) play key roles in the virulence of bacteria. In this study, we analyzed the expression levels of three critical genes in ciprofloxacin-resistant strains and ciprofloxacin-susceptible strains ofSalmonella, including outer membrane porin protein F (ompF), virulence genesinvAandinvE. In the clinical ciprofloxacin-resistant strains ofSalmonella, the expression level ofompFwas decreased. Meanwhile, the expression levels ofinvAandinvEwere decreased except for only one strain, indicating generally decreased virulence. These results were also verified with ciprofloxacin-induced resistant strains. Thus, it was informative for understanding the drug-resistance inSalmonella. Monitoring drug-resistance and virulence relevant genes would be significant in the prevention and control ofsalmonellosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据