Synthesis of novel thiazolo[3,2-a]chromeno[4,3-d]pyrimidine-6(7H)-ones by bioactive Fe3O4@gly@thiophen@Cu(NO3)2 as reusable magnetic nanocatalyst

In this study, new Fe3O4@gly@thiophen@Cu(NO3)(2) magnetic nanoparticles were synthesized. The final product was used as an efficient and novel magnetic nanocatalyst for synthesizing new derivatives of thiazolo[3,2-a] chromeno[4,3-d]pyrimidine-6(7H) in a short time and with higher efficiency. In the synthesis of Fe3O4@gly@thiophen@Cu(NO3)(2) magnetic nanoparticles, the use of glycine proved an inexpensive and readily available coating for Fe3O4 than previously reported materials, and the structure was confirmed using scanning electron microscopy, transmission electron microscopy, X-ray diffraction, energy-dispersive x-ray (EDX) spectroscopy, EDX mapping, Fourier-transform infrared spectroscopy, thermogravimetric analysis/derivative thermogravimetry, and vibrating sample magnetometry. The biological properties of magnetic nanoparticles were evaluated, and they exhibited acceptable antifungal and antibacterial properties in terms of minimum inhibitory concentration, minimum fungicidal concentration, and minimum bactericidal concentration.