期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 74, 2020
卷 74, 期 -, 页码 787-813出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-020420-013457
关键词
Enterobacteriaceae; Salmonella Typhimurium; gut microbiota; mouse model; diet; disease
类别
资金
- Swiss National Science Foundation (SNF) [310030B_173338/1, 310030_192567]
Food has a major impact on all aspects of health. Recent data suggest that food composition can also affect susceptibility to infections by enteropathogenic bacteria. Here, we discuss how food may alter the microbiota as well asmucosal defenses and how this can affect infection. Salmonella Typhimurium diarrhea serves as a paradigm, and complementary evidence comes from other pathogens. We discuss the effects of food composition on colonization resistance, host defenses, and the infection process as well as the merits and limitations of mouse models and experimental foods, which are available to decipher the underlying mechanisms.
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