期刊
ANNUAL REVIEW OF MICROBIOLOGY, VOL 74, 2020
卷 74, 期 -, 页码 337-359出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-022620-081059
关键词
synthetic biology; biotechnology; biosensor; gene circuit; biomedical applications; diagnosis; treatment
类别
The ability to detect disease early and deliver precision therapy would be transformative for the treatment of human illnesses. To achieve these goals, biosensors that can pinpoint when and where diseases emerge are needed. Rapid advances in synthetic biology are enabling us to exploit the information-processing abilities of living cells to diagnose disease and then treat it in a controlled fashion. For example, living sensors could be designed to precisely sense disease biomarkers, such as by-products of inflammation, and to respond by delivering targeted therapeutics in situ. Here, we provide an overview of ongoing efforts in microbial biosensor design, highlight translational opportunities, and discuss challenges for enabling sense-and-respond precision medicines.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据