期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89
卷 89, 期 -, 页码 417-442出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-013118-110729
关键词
ribosome stalling; translation; RQC; CAT tails; protein degradation; ubiquitin
资金
- US National Institutes of Health [R01GM115968]
- National Institute of General Medical Sciences of the US National Institutes of Health [T32GM007276]
- Stanford University
Stalled protein synthesis produces defective nascent chains that can harm cells. In response, cells degrade these nascent chains via a process called ribosome-associated quality control (RQC). Here, we review the irregularities in the translation process that cause ribosomes to stall as well as how cells use RQC to detect stalled ribosomes, ubiquitylate their tethered nascent chains, and deliver the ubiquitylated nascent chains to the proteasome. We additionally summarize how cells respond to RQC failure.
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