A novel 17 bp InDel polymorphism within thePPARGC1Agene is significantly associated with growth traits in sheep

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PPARGC1A) is a member of transcriptional coactivator of the peroxisome proliferator-activated receptor. It is involved in lipid metabolism, energy metabolism, adipocyte differentiation and regulation of mitochondrial biogenesis. Therefore, the genetic variation ofPPARGC1Agene will be of great value. The purposes of this study were to detect novel InDels within thePPARGC1Agene and analyze the effects of genetic polymorphisms on growth traits. We detected a novel 17 bp insertion polymorphism within the eleventh intron of the sheepPPARGC1Agene. Experimental results revealed that the InDel (insertion/deletion) genotypes distribution of the seven breeds of sheep was significant differences, of which three genotypes were detected. After correlation analysis, there were many significant phenotypic differences between the body size traits of the three genotypes. Interestingly, the dominant genotype was different in body weight both in STHS sheep and HS sheep. In summary, the 17 bp insertion polymorphism within thePPARGC1Agene had a great influence on the growth traits of sheep, which may provide a potential theoretical basis for marker-assisted selection in sheep genetic breeding.

Automated summary

This study identified a novel 17bp insertion polymorphism within the PPARGC1A gene in sheep, which significantly influenced their growth traits. These findings may provide a potential theoretical basis for marker-assisted selection in sheep genetic breeding.