期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 50, 页码 22431-22435出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202010089
关键词
fluorescent probes; gold nanoparticles; protein corona; red shift; tumor imaging
资金
- National Natural Science Foundation of China [21976126, 31671032]
- Key International Cooperation Projects of the Ministry of Science and Technology [2018YFE0120400]
- Key Project of social development of Jiangsu Province [BE2018653]
The application of NIR-II emitters for gastrointestinal (GI) tract imaging remains challenging due to fluorescence quenching in the digestive microenvironment. Herein, we report that red-shifting of the fluorescence emission of Au nanoclusters (AuNCs) into NIR-II region with improved quantum yields (QY) could be achieved by engineering a protein corona structure consisting of a ribonuclease-A (RNase-A) on the particle surfaces. RNase-A-encapsulated AuNCs (RNase-A@AuNCs) displayed emissions at 1050 nm with a 1.9 % QY. Compared to rare earth and silver-based NIR-II emitters, RNase-A@AuNCs had excellent biocompatibility, showing >50-fold higher sensitivity in GI tract, and migrated homogenously during gastrointestinal peristalsis to allow visualization of the detailed structures of the GI tract. RNase-A@AuNCs could successfully examine intestinal tumor mice from healthy mice, indicating a potential utility for early diagnosis of intestinal tumors.
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