期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 40, 页码 17540-17547出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202004805
关键词
core-shell nanostructures; DNA structures; drug delivery; hairpin aptamers; nanowires
资金
- National Natural Science Foundation of China (NSFC) [21775024]
- Key Project of Natural Science Foundation of Fujian Province [2019J02005]
- Research Foundation of Education Bureau of Hunan Province [19B384]
- Open Project of State Key Laboratory of Chemo/biosensing and Chemometrics [2016010]
- Cancer Center at Illinois
DNA nanostructures have shown potential in cancer therapy. However, their clinical application is hampered by the difficulty to deliver them into cancer cells and susceptibility to nuclease degradation. To overcome these limitations, we report herein a periodically ordered nick-hidden DNA nanowire (NW) with high serum stability and active targeting functionality. The inner core is made of multiple connected DNA double helices, and the outer shell is composed of regularly arranged standing-up hairpin aptamers. All termini of the components are hidden from nuclease attack, whereas the target-binding sites are exposed to allow delivery to the cancer target. The DNA NW remained intact during incubation for 24 h in serum solution. Animal imaging and cell apoptosis showed that NWs loaded with an anticancer drug displayed long blood-circulation time and high specificity in inducing cancer-cell apoptosis, thus validating this approach for the targeted imaging and therapy of cancers.
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