期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 52, 页码 23456-23460出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202007039
关键词
hypoxia detection; organic phosphorescence and fluorescence; ratiometric imaging; self-assembly; supramolecular chemistry
资金
- National Natural Science Foundation of China [22071258, 21871280, 21861132004]
- Ministry of Science and Technology of China [2017YFA0206903]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB17000000]
- Key Research Program of Frontier Sciences of the Chinese Academy of Sciences [QYZDY-SSW-JSC029]
- K.C. Wong Education Foundation
Hypoxia is a parameter related to many diseases. Ratiometric hypoxia probes often rely on a combination of an O-2-insensitive fluorophore and an O-2-sensitive phosphor in a polymer matrix, which require high cost and multi-step synthesis of transition metal complexes. The two-chromophore hypoxia probes encounter unfavorable energy transfer processes and different stabilities of the chromophores. Reported herein is a pure organic ratiometric hypoxia nanoprobe, assembled by a monochromophore, naphthalimide ureidopyrimidinone (BrNpA-UPy), bridged by a bis-UPy-functionalized benzyl skeleton. The joint factors of quadruple hydrogen bonding, the rigid backbone of UPy, and bromine substitution of the naphthalimide derivative facilitate bright phosphorescence (phi(P)=7.7 %,tau(P)=3.2 ms) and fluorescence of the resultant nanoparticles (SNPs) at room temperature, which enable accurate, ratiometric, sensitive oxygen detection (K-sv=189.6 kPa(-1)) in aqueous solution as well as in living HeLa cells.
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