期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 34, 页码 14686-14692出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202007226
关键词
C-H activation; cyclic peptides; macrocyclization; palladium catalysis; stapled peptide
资金
- NSF of China [21778030, 21861142005]
- Fundamental Research Funds for the Central Universities [14380138, 14380131]
Transition-metal-catalyzed C-H activation has shown potential in the functionalization of peptides with expanded structural diversity. Herein, the development of late-stage peptide macrocyclization methods by palladium-catalyzed site-selective C(sp(2))-H olefination of tryptophan residues at the C2 and C4 positions is reported. This strategy utilizes the peptide backbone as endogenous directing groups and provides access to peptide macrocycles with unique Trp-alkene crosslinks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据