期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 34, 页码 14347-14351出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202006016
关键词
arylation; arynes; asymmetric catalysis; electrochemistry; synthetic methods
资金
- Natural Science Foundation of China [21861132003, 21672217, 21521002]
- Tsinghua University Initiative Scientific Research Program
- National Program of Top-notch Young Professionals
Asymmetric catalysis with benzyne remains elusive because of the highly fleeting and nonpolar nature of benzyne intermediates. Reported herein is an electrochemical approach for the oxidative generation of benzynes (cyclohexyne) and its successful merging with chiral primary aminocatalysis, formulating the first catalytic asymmetric enamine-benzyne (cyclohexyne) coupling reaction. Cobalt acetate was identified to stabilize the in situ generated arynes and facilitate its coupling with an enamine. This catalytic enamine-benzyne protocol provides a concise method for the construction of diverse alpha-aryl (alpha-cyclohexenyl) quaternary carbon stereogenic centers with good stereoselectivities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据