期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 46, 页码 20470-20474出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202009636
关键词
alkenes; gold redox catalysis; hemilabile (P; N) ligands; oxidative addition; oxyarylation
资金
- NSF [CHE-1665122]
- NIH [1R01GM120240-01]
- University of South Florida Interdisciplinary NMR Facility
- Chemical Purification, Analysis, and Screening (CPAS) Core Facility
The gold-catalyzed intermolecular oxyarylation of alkenes is reported. This work employed the oxidative addition of aryl iodides to Me-DalphosAu(+)for the formation of a Au-III-Ar intermediate. The better binding ability of alkenes over O nucleophiles ensured the success of intermolecular oxyarylation, giving desired products with a broad substrate scope and high efficiency (>50 examples with up to 95 % yield). One-pot converting of methoxy groups into other nucleophiles allowed achieving alkene difunctionalization with the construction of C-N, C-S, and C-C bonds under mild conditions.
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