SERS-Active MIL-100(Fe) Sensory Array for Ultrasensitive and Multiplex Detection of VOCs

The application of metal-organic frameworks (MOFs) as SERS-active platforms in multiplex volatile organic compounds (VOCs) detection is still unexplored. Herein, we demonstrate that MIL-100 (Fe) serves as an ideal SERS substrate for the detection of VOCs. The limit of detection (LOD) of MIL-100(Fe) for toluene sensing can reach 2.5 ppm, and can be even further decreased to 0.48 ppb level when hot spots in between Au nanoparticles are employed onto MIL-100 (Fe) substrate, resulting in an enhancement factor of 10(10). Additionally, we show that MIL-100(Fe) substrate has a unique sensor array property allowing multiplex VOCs detection, with great modifiability and expandability by doping with foreign metal elements. Finally, the MIL-100(Fe) platform is utilized to simultaneously detect the different gaseous indicators of lung cancer with ppm detection limit, demonstrating its high potential for early diagnosis of lung cancer in vivo.