期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 23, 页码 12682-12705出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202008386
关键词
cancer therapy; electromagnetic energy; immunogenic cell death; immunotherapy; nanomedicine
资金
- Nanyang Technological University [NTU-SUG: M4081627.120]
- Singapore Ministry of Education [2017-T1-002-134, 2018-T1-001-173, 2019-T1-002-045, MOE2018-T2-2-042]
- Agency for Science, Technology and Research (AME Programmatic Grant) [SERC A18A8b0059]
Immunotherapy harnesses the immune system to eliminate malignant cells, but faces challenges such as limited patient response rates and immune-related adverse events. Electromagnetic nanomaterials can induce immunogenic cell death and are used in combination with cancer immunotherapy for reprogramming the tumor microenvironment.
Immunotherapy that harnesses the power of the immune system to eliminate malignant cells has offered an effective approach for cancer treatment. However, limited patient response rates and potential immune-related adverse events exist as two major issues for cancer immunotherapy. In parallel, a variety of electromagnetic nanomaterials that generate heat and/or reactive oxygen species triggered by electromagnetic energy have been applied for magnetic hyperthermia therapy, sonodynamic therapy, photothermal therapy, photodynamic therapy, and radiotherapy, which have the ability to induce immunogenic cell death. This review summarizes the recent development of electromagnetic nanomedicines in combinational cancer immunotherapy. The mechanisms of electromagnetic nanomedicines in reprogramming the immunosuppressive tumor microenvironment and sensitizing tumors for cancer immunotherapy are highlighted. Furthermore, potential challenges and perspectives of electromagnetic nanomedicines for combinational cancer immunotherapy are discussed.
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