期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 37, 页码 16091-16097出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202005102
关键词
DNA nanotechnology; DNA structures; fluorescence; self-assembly; silver
资金
- Korea Research Fellowship Program - Ministry of Science and ICT [NRF2017H1D3A1A01014182, NRF-2017M2A2A6A04093177]
- NovoNordisk Foundation [NNF16OC0021832, NNF17OC0029548]
- National Research Foundation of Korea [4199990314020] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Fluorescent, DNA-stabilized silver nanoclusters (DNA-AgNCs) are applied in a range of applications within nanoscience and nanotechnology. However, their diverse optical properties, mechanism of formation, and aspects of their composition remain unexplored, making the rational design of nanocluster probes challenging. Herein, a synthetic procedure is described for obtaining a high yield of emissive DNA-AgNCs with a C-loop hairpin DNA sequence, with subsequent purification by size-exclusion chromatography (SEC). Through a combination of optical spectroscopy, gel electrophoresis, inductively coupled plasma mass spectrometry (ICP-MS), and small-angle X-ray scattering (SAXS) in conjunction with the systematic study of various DNA sequences, the low-resolution structure and mechanism of the formation of AgNCs were investigated. Data indicate that fluorescent DNA-AgNCs self-assemble by a head-to-head binding of two DNA hairpins, bridged by a silver nanocluster, resulting in the modelling of a dimeric structure harboring an Ag(12)cluster.
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