期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 41, 页码 18078-18086出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202008858
关键词
drug delivery; heteroepitaxial growth; heterostructures; metal-organic frameworks; MOF-on-MOF
资金
- National Natural Science Foundation of China [51903192, 51833007, 51690152, 21721005]
- China Postdoctoral Science Foundation [2019M652695]
Multi-component MOFs contain multiple sets of unique and hierarchical pores, with different functions for different applications, distributed in their inter-linked domains. Herein, we report the construction of a class of precisely aligned flexible-on-rigid hybrid-phase MOFs with a unique rods-on-octahedron morphology. We demonstrated that hybrid-phase MOFs can be constructed based on two prerequisites: the partially matched topology at the interface of the two frameworks, and the structural flexibility of MOFs withacstopology, which can compensate for the differences in lattice parameters. Furthermore, we achieved domain selective loading of multiple guest molecules into the hybrid-phase MOF, as observed by scanning transmission electron microscopy-energy-dispersive X-ray spectrometry elemental mapping. Most importantly, we successfully applied the constructed hybrid-phase MOF to develop a dual-drug delivery system with controllable loading ratio and release kinetics.
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