期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 46, 页码 20450-20454出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202008482
关键词
carbagermatranes; Catellani reaction; ipso-alkylation; main-group chemistry; organogermanium compounds
资金
- National Key R&D Program of China [2017YFA0700104]
- NSFC [21871239]
- Fundamental Research Funds for the Central Universities [WK2060190081]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences [Y201987]
The Catellani reaction has received substantial attention because it enables rapid multiple derivatization on aromatics. While using alkyl electrophiles to achieveortho-alkylation was one of the earliest applications of the Catellani reaction,ipso-alkylation-terminated reactions with beta-H-containing reactants has not been realized to date. Herein, we report alkylation-terminated Catellani reaction using alkyl carbagermatranes (abbreviated as alkyl-Ge) as nucleophiles. The reactivity of alkyl-Geand alkyl-B(OH)(2)in this reaction is discussed. This approach enables efficient dialkylation with beta-H-containing reactants, which was previously inaccessible by Catellani reactions.
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