期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 43, 页码 19222-19228出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202007825
关键词
cascade reaction; iron catalysis; N-heterocycles; oximes; synthetic methods
资金
- NSFC [21772231]
- National Key R&D program of China [2018YFA0507900]
- China Postdoctoral Science Foundation [2018M633761]
- Army Medical University
By integration of iminyl radical-triggered 1,5-hydrogen atom transfer and (5+2) or (5+1) annulation processes, a series of structurally novel and interesting azepine and spiro-tetrahydropyridine derivatives have been successfully prepared in moderate to good yields. This method utilizes FeCl(2)as the catalyst and readily available oximes as five-atom units, while showcasing broad substrate scope and good functional group compatibility. The annulation products can be easily converted into many valuable compounds. Moreover, DFT calculation studies are performed to provide some insights into the possible reaction mechanisms for the (5+2) and (5+1) annulations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据