期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 46, 页码 20568-20576出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202008379
关键词
2D materials; black phosphorus; nanoparticles; quantum dots; chronic obstructive pulmonary disease
资金
- National Key R&D Program of China [2017YFC1309300]
- National Natural Science Foundation of China [21975280, 31922040]
- Natural Science Foundation of Guangdong Province, China [2020A1515010613]
- Guangdong Special Support Program [2017TX04C096]
- Youth Innovation Promotion Association of Chinese Academy of Sciences [2017416]
- Leading Talents of Guangdong Province Program [00201520]
- City University of Hong Kong Strategic Research Grant (SRG) [7005264]
- Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [CityU 11205617]
Chronic obstructive pulmonary disease (COPD) is an intractable disease involving a sticky mucus layer and nanoagents with mucus-penetrating capability offer a new way to deliver drugs. However, drug release from nanovehicles requires optimization to enhance the therapeutic effects of COPD therapy. Herein, black phosphorus quantum dots (BPQDs) are combined with PEGylated chitosan nanospheres containing the antibiotic amikacin (termed PEG@CS/BPQDs-AM NPs). As a drug-delivery system, the hydrophilicity of PEG and positive charge of CS facilitate the penetration of nanovehicles through the mucus layer. The nanovehicles then adhere to the mucous membrane. Furthermore, the BPQDs degrade rapidly into nontoxic PO(4)(3-)and acidic H+, thereby promoting the dissociation of PEGylated CS nanospheres, accelerating the release of AM, decreasing the vitality of biofilms for ease of eradication. Our results reveal that drug delivery mediated by BPQDs is a feasible and desirable strategy for precision medicine and promising for the clinical therapy of COPD.
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