期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 46, 页码 20636-20644出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202009141
关键词
activatable probes; disassembly; imaging; photodynamic therapy; self-assembly
资金
- National Key R&D Program of China [2017YFA0701301]
- National Natural Science Foundation of China [21922406, 21775071, 21632008]
- Natural Science Foundation of Jiangsu Province [BK20190055]
- Fundamental Research Funds for the Central Universities [020514380185]
- Excellent Research Program of Nanjing University [ZYJH004]
Stimuli-responsive smart photosensitizer (PS) nanoassemblies that allow enhanced delivery and controlled release of PSs are promising for imaging-guided photodynamic therapy (PDT) of tumors. However, the lack of high-sensitivity and spatial-resolution signals and fast washout of released PSs from tumor tissues have impeded PDT efficacy in vivo. Herein, we report tumor targeting, redox-responsive magnetic and fluorogenic PS nanoassemblies (NP-RGD) synthesized via self-assembly of a cRGD- and disulfide-containing fluorogenic and paramagnetic small molecule (1-RGD) for fluorescence/magnetic resonance bimodal imaging-guided tumor PDT.NP-RGDshow highr(1)relaxivity but quenched fluorescence and PDT activity; disulfide reduction by glutathione (GSH) promotes efficient disassembly into a small-molecule probe (2-RGD) and an organic PS (PPa-SH), which could further bind with intracellular albumin, allowing prolonged retention and cascade activation of fluorescence and PDT to ablate tumors.
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