期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 45, 页码 19773-19786出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202008437
关键词
asymmetric catalysis; C-H activation; chiral transient directing group; enantioselectivity; total synthesis
资金
- NSFC [21901228, 21925109, 21772170]
- Out-standing Young Talents of Zhejiang Province High-level Personnel of Special Support [ZJWR0108]
- Fundamental Research Funds for the Central Universities [2018XZZX001-02]
Transition metal-catalyzed enantioselective functionalization of C-H bond, the most abundant functionality in organic molecules, has emerged as an expedient synthetic approach to streamline the synthesis of complex chiral molecules. Despite significant progress, traditional directing group-enabled strategies require additional steps for the installation and removal of directing groups from the target molecule. The recently developed asymmetric C-H functionalization using chiral transient directing groups (cTDGs) offers a promising alternative that can circumvent this obstacle and therefore simplify the process. In this Minireview, we briefly discuss the advent and recent advances of this emerging concept, with an emphasis on discussing the creation of various stereogenic centers and the developments ofcTDGs. Applications in natural product synthesis and ligand derivatizations are also discussed. We hope this Minireview will highlight the great potential of this strategy and help to inspire further endeavors.
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