期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 43, 页码 19229-19236出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202007878
关键词
autolysosome; platinum complexes; real-time tracking; Stokes shift; super-resolution imaging
资金
- National Science Foundation of China [21837006, 91953117]
- Ministry of Education of China [IRT-17R111]
- Fundamental Research Funds for the Central Universities
- HKU University Research Committee (URC) Strategically Oriented Research Theme (SORT) on Functional Materials for Molecular Electronics
- General Research Fund (GRF) grant from the Research Grants Council of the Hong Kong Special Administrative Region, People's Republic of China [HKU 17306219]
- Department of Cancer Biology, University of Cincinnati College of Medicine
- Academic Promotion Program of Shandong First Medical University [2019LJ003]
It is of great significance to track the platinum drugs in real time with super-resolution to elucidate their mechanism of action, such as their behavior and distribution in live cells. Such information is required for further drug development. However, it is always challenging to design platinum complexes suitable for such research. Herein, we design a luminescent building block (L) for metal complexes and a dinuclear platinum complex (Pt2L) for super-resolution imaging. Because of its super-large Stokes shift and excellent photophysical properties,Pt(2)Lis capable of serving as an ideal candidate for super-resolution imaging with extremely low luminescence background and high photobleaching resistance. Moreover, upon light stimulation, a matter flux ofPt(2)Lescaping from autolysosomes to nucleus was observed, which represents a new transportation path. Utilizing the photoactivated escape properties, we can regulate the nuclear accessibility ofPt(2)Lform autolysosomes with photo-selectivity, which provides a new way to improve the targeting of platinum drugs.
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