期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 46, 页码 20515-20521出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202004183
关键词
benzene bioisosteres; bicyclo[1; 1; 1]pentanes; bioisosterism; conformational restriction; ortho-substituted benzenes
Saturated bioisosteres ofortho-disubstituted benzenes (bicyclo[2.1.1]hexanes) were synthesized, characterized and validated. These cores were incorporated into the bioactive compoundsValsartan, BoskalidandFluxapyroxadinstead of the benzene ring. The saturated analogues showed a similar level of antifungal activity compared to that ofBoskalidandFluxapyroxad.
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