期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 6, 页码 2757-2767出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202007754
关键词
cells; electrochemical sensing; mechanotransduction; stretchable electrodes; tissues
资金
- National Natural Science Foundation of China [21725504, 21675121, 21804101, 21721005]
- Open Funds of the State Key Laboratory of Electroanalytical Chemistry [SKLEAC201908]
- China Postdoctoral Science Foundation [2017M620329, 2018T110790]
- Chinese Fundamental Research Funds for the Central Universities [2042019kf0274]
This review discusses the applications of stretchable sensors in real-time monitoring of mechanically sensitive cells and tissues, while also exploring the future possibilities and challenges of stretchable electrochemical sensing in cell, tissue, and in vivo detection.
Electrochemical sensing based on conventional rigid electrodes has great restrictions for characterizing biomolecules in deformed cells or soft tissues. The recent emergence of stretchable sensors allows electrodes to conformally contact to curved surfaces and perfectly comply with the deformation of living cells and tissues. This provides a powerful strategy to monitor biomolecules from mechanically deformed cells, tissues, and organisms in real time, and opens up new opportunities to explore the mechanotransduction process. In this minireview, we first summarize the fabrication of stretchable electrodes with emphasis on the nanomaterial-enabled strategies. We then describe representative applications of stretchable sensors in the real-time monitoring of mechanically sensitive cells and tissues. Finally, we present the future possibilities and challenges of stretchable electrochemical sensing in cell, tissue, and in vivo detection.
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