期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 46, 页码 20697-20703出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202009888
关键词
bioinorganic chemistry; carbon radicals; medicinal inorganic chemistry; metals in medicine; photodynamic therapy
资金
- National Science Foundation of China [21525105, 21778079, 21977126]
- Ministry of Education of China [IRT-17R111]
- Fundamental Research Funds for the Central Universities of China [20lgjc01]
- Pearl River S&T Nova Program of Guangzhou [201806010136]
The efficacy of photodynamic therapy is typically reliant on the local concentration and diffusion of oxygen. Due to the hypoxic microenvironment found in solid tumors, oxygen-independent photosensitizers are in great demand for cancer therapy. We herein report an iridium(III) anthraquinone complex as a mitochondrion-localized carbon-radical initiator. Its emission is turned on under hypoxic conditions after reduction by reductase. Furthermore, its two-photon excitation properties (lambda(ex)=730 nm) are highly desirable for imaging. Upon irradiation, the reduced form of the complex generates carbon radicals, leading to a loss of mitochondrial membrane potential and cell death (IC50light=2.1 mu m, IC50dark=58.2 mu m, PI=27.7). The efficacy of the complex as a PDT agent was also demonstrated under hypoxic conditions in vivo. To the best of our knowledge, it is the first metal-complex-based theranostic agent which can generate carbon radicals for oxygen-independent two-photon photodynamic therapy.
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