期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 48, 页码 21706-21710出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202009335
关键词
C-H functionalization; enantioselectivity; nitrenoids; oxygenation; ruthenium
资金
- Deutsche Forschungsgemeinschaft [ME 1805/15-1]
- National Science Foundation [CHE-1764328, OCI-1053575]
- Projekt DEAL
This study demonstrates for the first time that easily accessible transition-metal acylnitrenoids can be used for controlled direct C(sp(3))-H oxygenations. Specifically, a ruthenium catalyst activates N-benzoyloxycarbamates as nitrene precursors towards regioselective intramolecular C-H oxygenations to provide cyclic carbonates, hydroxylated carbamates, or 1,2-diols. The method can be applied to the chemoselective C-H oxygenation of benzylic, allylic, and propargylic C(sp(3))-H bonds. The reaction can be performed in an enantioselective fashion and switched in a catalyst-controlled fashion between C-H oxygenation and C-H amination. This work provides a new reaction mode for the regiocontrolled and stereocontrolled conversion of C(sp(3))-H into C(sp(3))-O bonds.
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