期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 412, 期 25, 页码 6691-6705出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-020-02774-7
关键词
Aptamer; Biosensing; Bioimaging; Cancer diagnostics; Fluorescence; Colorimetry
资金
- National Natural Science Foundation of China [8150140715, 81503463, 81801792]
- Natural Science Foundation of Jiangsu Province of China [BK20170389]
- Science and Technology Program of Suzhou [SS201867]
Aptamers are chemically synthetic single-stranded DNA or RNA molecules selected by molecular evolution. They have been widely used as attractive tools in biosensing and bioimaging because they can bind to a large variety of targets with high sensitivity and high affinity and specificity. As recognition elements, aptamers contribute in particular to cancer diagnostics by recognizing different cancer biomarkers, while they can also facilitate ultrasensitive detection by further employing signal amplification elements. Optical techniques have been widely used for direct and real-time monitoring of cancer-related biomolecules and bioprocesses due to the high sensitivity, quick response, and simple operation, which has greatly benefited cancer diagnostics. In this review, we highlight recent advances in optical platform-based sensing strategies for cancer diagnostics aided by aptamers. Limitations and current challenges are also discussed.
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