期刊
AMINO ACIDS
卷 52, 期 6-7, 页码 1063-1065出版社
SPRINGER WIEN
DOI: 10.1007/s00726-020-02870-z
关键词
ACE2; COVID-19; SARS-CoV-2; Age
Gastrointestinal symptoms are common in COVID-19 patients, especially in younger patients. Our hypothesis was that intestinal SARS-CoV-2 receptor ACE2 expression depends on patients' age. We examined duodenal biopsies from 43 healthy human adults. ACE2 gene expression was directly correlated with age (Spearman'sr = 0.317,p = 0.039). With each year, duodenal ACE2 expression increased by 0.083 RU. The higher intestinal ACE2 mRNA expression in older patients may impact on their susceptibility to develop intestinal symptoms.
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