期刊
BLOOD
卷 125, 期 12, 页码 1932-1935出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2014-07-590166
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资金
- Celgene
- MRC [MR/L01629X/1, G0100132] Funding Source: UKRI
- Medical Research Council [MR/L01629X/1, G0100132] Funding Source: researchfish
The detection of minimal residual disease (MRD) in myeloma using a 0.01% threshold (10(-4)) after treatment is an independent predictor of progression-free survival (PFS), but not always of overall survival (OS). However, MRD level is a continuous variable, and the predictive value of the depth of tumor depletion was evaluated in 397 patients treated intensively in the Medical Research Council Myeloma IX study. There was a significant improvement in OS for each log depletion in MRD level (median OS was 1 year for >= 10%, 4 years for 1% to <10%, 5.9 years for 0.1% to <1%, 6.8 years for 0.01% to <0.1%, and more than 7.5 years for <0.01% MRD). MRD level as a continuous variable determined by flow cytometry independently predicts both PFS and OS, with approximately 1 year median OS benefit per log depletion. The trial was registered at www.isrctn.com as #68454111.
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