期刊
BLOOD
卷 126, 期 8, 页码 943-949出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2015-05-567859
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资金
- Eric Trump Foundation
- Gabrielle Angel Foundation
- American Lebanese Syrian Associated Charities of St. Jude Children's Research Hospital
Acute megakaryoblastic leukemia (AMKL) comprises between 4% and 15% of newly diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down syndrome (DS) is characterized by a founding GATA1 mutation that cooperates with trisomy 21, followed by the acquisition of additional somatic mutations. In contrast, non-DS-AMKL is characterized by chimeric oncogenes consisting of genes known to play a role in normal hematopoiesis. CBFA2T3-GLIS2 is the most frequent chimeric oncogene identified to date in this subset of patients and confers a poor prognosis.
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