Novel predictive and therapeutic options for better pregnancy outcome in frozen embryo transfer cycles

Since 1978, in the first decades of in vitro fertilization (IVF), the use of ovarian hyperstimulation allowed for the development and transfer of multiple embryos. As IVF technology improved, the number of multiple pregnancies increased, which led to gradual reduction in the number of embryos that were transferred. Embryo freezing (vitrification) was recommended to allow subsequent transfer if the fresh cycle was unsuccessful. However, experimentation has continued to improve pregnancy outcomes. We discuss here the significance of frozen embryo transfer cycle and the impact of uterine and peripheral immunity dominated by NK cells and regulatory T cells and human chorionic gonadotropin on pregnancy outcome in this innovative mode of IVF therapy.

Automated summary

The advancement of IVF technology has led to an increase in multiple pregnancies, but the use of embryo freezing techniques has resulted in a gradual reduction in the number of embryos transferred, further improving pregnancy success rates.