期刊
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
卷 319, 期 2, 页码 R171-R183出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.00259.2019
关键词
body weight; exercise; food intake; sex differences
类别
资金
- National Institutes of Health [F31 DK115238, TL1 TR001081, KL2 TR002534, P50 HD073063, R01 CA164166, U54 AG062319, P30 NORC DK48520]
- Animal Behavior Core at the University of Colorado, Anschutz Medical Campus
Exercise is often used as a strat-egy for weight loss maintenance. In preclinical models, we have shown that exercise may be beneficial because it counters the biolog-ical drive to regain weight. However, our studies have demonstrated sex differences in the response to exercise in this context. In the present study, we sought to better understand why females and males exhibit different compensatory food eating behaviors in response to regular exercise. Using a forced treadmill exercise paradigm, we measured weight gain, energy expenditure, food intake in real time, and the anorectic effects of leptin. The 4-wk exercise training resulted in reduced weight gain in males and sustained weight gain in females. In male rats, exercise decreased intake, whereas it increased food intake in females. Our results suggest that the anorectic effects of leptin were not responsible for these sex differences in appetite in response to exercise. If these results translate to the human condition, they may reveal important information for the use and application of regular exercise programs.
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