期刊
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
卷 319, 期 3, 页码 L444-L455出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajplung.00252.2020
关键词
coronaviruses; coronavirus disease 2019 (COVID-19); miRNA sponges; SARS-CoV; UPR
资金
- National Science Center [2015/18/E/NZ3/00687, 2015/17/B/NZ3/01485]
- National Science Foundation, National Science Center Program Opportunities for Promoting Understanding through Synthesis (OPUS) [2014/13/B/NZ3/02393]
- NIH National Institute of Diabetes and Digestive and Kidney Diseases [P30 DK072482]
- Cystic Fibrosis Foundation [ROWE15R0]
Cold viruses have generally been considered fairly innocuous until the appearance of the severe acute respiratory coronavirus 2 (SARS-CoV-2) in 2019, which caused the coronavirus disease 2019 (COVID-19) global pandemic. Two previous viruses foreshadowed that a coronavirus could potentially have devastating consequences in 2002 [severe acute respiratory coronavirus (SARS-CoV)] and in 2012 [Middle East respiratory syndrome coronavirus (MERS-CoV)]. The question that arises is why these viruses are so different from the relatively harmless cold viruses. On the basis of an analysis of the current literature and using bioinformatic approaches, we examined the potential human miRNA interactions with the SARS-CoV-2's genome and compared the miRNA target sites in seven coronavirus genomes that include SARS-CoV-2, MERS-CoV, SARS-CoV, and four nonpathogenic coronaviruses. Here, we discuss the possibility that pathogenic human coronaviruses, including SARS-CoV-2, could modulate host miRNA levels by acting as miRNA sponges to facilitate viral replication and/or to avoid immune responses.
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