期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 189, 期 12, 页码 1521-1528出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwaa087
关键词
BMI; FVC; physical activity; restrictive spirometry; spirometry
资金
- Ageing Lungs in European Cohorts (ALEC) Study from the European Union's Horizon 2020 research and innovation program [633212]
- National Science Foundation [33CS30-177506]
- Swiss National Science Foundation (SNF) [33CS30_177506] Funding Source: Swiss National Science Foundation (SNF)
We estimated the association between regular physical activity and the incidence of restrictive spirometry pattern. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and physical activity were assessed in 2 population-based European cohorts (European Community Respiratory Health Survey: n = 2,757, aged 39-67 years; and Swiss Study on Air Pollution and Lung and Heart Diseases in Adults: n = 2,610, aged 36-82 years) first in 2000-2002 and again approximately 10 years later (2010-2013). Subjects with restrictive or obstructive spirometry pattern at baseline were excluded. We assessed the association of being active at baseline (defined as being physically active at least 2-3 times/week for >= 1 hour) with restrictive spirometry pattern at follow-up (defined as a postbronchodilation FEV1/FVC ratio of at least the lower limit of normal and FVC of <80% predicted) using modified Poisson regression, adjusting for relevant confounders. After 10 years of follow-up, 3.3% of participants had developed restrictive spirometry pattern. Being physically active was associated with a lower risk of developing this phenotype (relative risk = 0.76, 95% confidence interval: 0.59, 0.98). This association was stronger among those who were overweight and obese than among those of normal weight (P for interaction = 0.06). In 2 large European studies, adults practicing regular physical activity were at lower risk of developing restrictive spirometry pattern over 10 years.
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