期刊
ALZHEIMERS & DEMENTIA
卷 16, 期 9, 页码 1280-1292出版社
WILEY
DOI: 10.1002/alz.12128
关键词
genetic pleiotropy; inflammation and immune-based pathways and Alzheimer's disease; late-onset Alzheimer's disease; MS4A gene family; posttraumatic stress disorder; PTSD
资金
- National Institutes of Health/National Institute of Aging [R56 AG062302-01, R01AG057522]
Introduction: Late-onset Alzheimer's disease (LOAD) manifests comorbid neuropsychiatric symptoms and posttraumatic stress disorder (PTSD) is associated with an increased risk for dementia in late life, suggesting the two disorders may share genetic etiologies. Methods: We performed genetic pleiotropy analysis using LOAD and PTSD genome-wide association study (GWAS) datasets from white and African-American populations, followed by functional-genomic analyses. Results: We found an enrichment for LOAD across increasingly stringent levels of significance with the PTSD GWAS association (LOAD vertical bar PTSD) in the discovery and replication cohorts and a modest enrichment for the reverse conditional association (PTSD vertical bar LOAD). LOAD vertical bar PTSD association analysis identified and replicated the MS4A genes region. These genes showed similar expression pattern in brain regions affected in LOAD, and across-brain-tissue analysis identified a significant association for MS4A6A. The African-American samples showed moderate enrichment; however, no false discovery rate-significant associations. Discussion: We demonstrated common genetic signatures for LOAD and PTSD and suggested immune response as a common pathway for these diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据