期刊
AIDS
卷 34, 期 12, 页码 1789-1794出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0000000000002632
关键词
comorbidity burden; coronavirus disease 2019; HIV; persons living with HIV; severe acute respiratory syndrome coronavirus 2
资金
- Emory Center for AIDS Research [P30-AI-050409]
- Emory Specialized Center of Research Excellence (SCORE) on Sex Differences [U54AG062334]
- National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) [UL1TR002378, TL1TR002382]
- NCATS of the NIH [KL2TR002381]
- National Institute of Allergy and Infectious Diseases (NIAID) of the NIH [K23-AI124913]
Background: There are limited data describing the presenting characteristics and outcomes among US persons with HIV (PWH) requiring hospitalization for coronavirus disease 2019 (COVID-19). Methods: We performed a case series of all PWH sequentially admitted with COVID-19 from 8 March 2020 to 23 April 2020 at three hospitals in Atlanta, Georgia. Sociodemographic, clinical and HIV-associated characteristics were collected. Results: Of 530 confirmed COVID-19 cases hospitalized during this period, 20 occurred among PWH(3.8%). The median age was 57 (Q1-Q3, 48-62) years, 65% were men, and 85% were non-Hispanic Black. Presenting median symptom duration was 5 (Q1-Q3, 37) days; cough (90%), fever (65%), malaise (60%) and dyspnea (60%) were most common. On admission, 40% of patients required oxygenation support and 65% had an abnormal chest radiograph. Median length of hospitalization was 5 (Q1-Q3, 4-12) days, 30% required intensive care, 15% required intubation, and 15% died. Median CD4(+) cell count prior to admission was 425 (Q1-Q3, 262-815) cells/mu l and 90% of patients had HIV-1 RNA less than 200 copies/mu l. Half of the patients had at least five comorbidities; hypertension (70%), dyslipidemia (60%) and diabetes (45%) were most prevalent. All three patients who died had CD4(+) cell count more than 200, HIV suppression and each had a total of five comorbidities. Conclusion: The multisite series in the Southern United States provides characteristics and early outcomes of hospitalized PWH with COVID-19. Nearly all patients had controlled HIV and a high comorbidity burden. Additional study of COVID-19 among PWH is needed to determine the role of age, comorbidities and HIV control in mediating COVID-19 presentation and its sequelae. Copyright (C) 2020 Wolters Kluwer Health, Inc. All rights reserved.
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