期刊
AGING-US
卷 12, 期 13, 页码 12441-12467出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.103619
关键词
dietary restriction; living kidney donation; kidney transplantation; kidney function; acute rejection
资金
- National Institute for Public Health and the Environment
- Ministry of Health, Welfare and Sports of The Netherlands [S/340005]
- National Institute of Health (NIH)/National Institute of Ageing (NIA) [PO1 AG017242]
- European Research Council Advanced Grants DamAge
- KWO Dutch Cancer Society [5030]
Previously, we and others showed that dietary restriction protects against renal ischemia-reperfusion injury in animals. However, clinical translation of preoperative diets is scarce, and in the setting of kidney transplantation these data are lacking. In this pilot study, we investigated the effects of five days of a preoperative protein and caloric dietary restriction (PCR) diet in living kidney donors on the perioperative effects in donors, recipients and transplanted kidneys. Thirty-five kidney donors were randomized into either the PCR, 30% calorie and 80% protein reduction, or control group without restrictions. Adherence to the diet and kidney function in donors and their kidney recipients were analyzed. Perioperative kidney biopsies were taken in a selected group of transplanted kidneys for gene expression analysis. All donors adhered to the diet. From postoperative day 2 up until month 1, kidney function of donors was significantly better in the PCR-group. PCR-donor kidney recipients showed significantly improved kidney function and lower incidence of slow graft function and acute rejection. PCR inhibited cellular immune response pathways and activated stress-resistance signaling. These observations are the first to show that preoperative dietary restriction induces postoperative recovery benefits in humans and may be beneficial in clinical settings involving ischemia-reperfusion injury.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据