期刊
AGING-US
卷 12, 期 16, 页码 -出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.103725
关键词
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资金
- European Research Council Research Grant [ERC-2012-StG311000]
- UCD Wellcome Institutional Strategic Support Fund - University College Dublin [204844/Z/16/Z]
- UCD Wellcome Institutional Strategic Support Fund - SFI-HRB-Wellcome Biomedical Research Partnership [204844/Z/16/Z]
- Irish Research Council Consolidator Laureate Award
Bats are the longest-lived mammals given their body size with majority of species exhibiting exceptional longevity. However, there are some short-lived species that do not exhibit extended lifespans. Here we conducted a comparative genomic and transcriptomic study on long-lived Myotis myotis (maximum lifespan = 37.1 years) and short-lived Molossus molossus (maximum lifespan = 5.6 years) to ascertain the genetic difference underlying their divergent longevities. Genome-wide selection tests on 12,467 single-copy genes between M. myotis and M. molossus revealed only three genes (CCDC175, FATE1 and MLKL) that exhibited significant positive selection. Although 97.96% of 12,467 genes underwent purifying selection, we observed a significant heterogeneity in their expression patterns. Using a linear mixed model, we obtained expression of 2,086 genes that may truly represent the genetic difference between M. myotis and M. molossus. Expression analysis indicated that long-lived M. myotis exhibited a transcriptomic profile of enhanced DNA repair and autophagy pathways, compared to M. molossus. Further investigation of the longevity associated genes suggested that long-lived M. myotis have naturally evolved a diminished anti-longevity transcriptomic profile. Together with observations from other long-lived species, our results suggest that heightened DNA repair and autophagy activity may represent a universal mechanism to achieve longevity in long-lived mammals.
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