期刊
AGING CELL
卷 19, 期 7, 页码 -出版社
WILEY
DOI: 10.1111/acel.13167
关键词
aging; Caenorhabditis elegans; human; repetitive elements; transcriptomics; transposable elements
资金
- National Institute on Aging [AG060302]
Transcriptomic markers of aging can be useful for studying age-related processes and diseases. However, noncoding repetitive element (RE) transcripts, which may play an important role in aging, are commonly overlooked in transcriptome studies-and their potential as a transcriptomic marker of aging has not been evaluated. Here, we used multiple RNA-seq datasets generated from human samples and Caenorhabditis elegans and found that most RE transcripts (a) accumulate progressively with aging; (b) can be used to accurately predict age; and (c) may be a good marker of biological age. The strong RE/aging correlations we observed are consistent with growing evidence that RE transcripts contribute directly to aging and disease.
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