期刊
AGEING RESEARCH REVIEWS
卷 60, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2020.101043
关键词
Plasma; Fatty acids (FA); Mild cognitive impairment (MCI); Alzheimer's disease (AD); Docosahexaenoic acid (DHA); Meta analysis
资金
- National Health & Medical Research Council of Australia [APP1054544]
- Australian Research Council Postdoctoral Research Fellowship
- Rebecca Cooper Medical Research Foundation
- Sachdev Foundation
Plasma fatty acids have been reported to be dysregulated in mild cognitive impairment (MCI) and Alzheimer's disease (AD), though outcomes are not always consistent, and subject numbers often small. Our aim was to use a meta-analysis and systematic review approach to identify if plasma fatty acid dysregulation would be observed in case control studies of AD and MCI. Six databases were searched for studies reporting quantified levels of fatty acids in MCI and/or AD individuals, relative to cognitively normal controls. Docosahexaenoic (DHA) and vaccenic acids were significantly lower and higher respectively in MCI relative to controls. Total fatty acids were 27.2% lower in AD relative to controls, and this was reflected almost uniformly in all specific fatty acids in AD. Changes to plasma/serum fatty acids were identified in both MCI and AD relative to age and gender matched controls. Differences were greatest in AD, in both total number of fatty acids significantly altered, and the degree of change. Docosahexaenoic acid was lower in both MCI and AD, suggesting that it may be a driver of pathology.
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