期刊
ADVANCED MATERIALS
卷 32, 期 31, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202000038
关键词
fenton reaction; graphdiyne oxide; iron sponge; photothermal therapy
类别
资金
- National Key R&D Program of China [2018YFA0208900]
- Strategic Priority Research Program of Chinese Academy of Sciences [XDB36000000]
- National Natural Science Foundation of China [91543127, 51573191]
- Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS, China Postdoctoral Science Foundation [2019TQ0285, 2019M662513]
Fenton reaction-mediated oncotherapy is an emerging strategy which uses iron ions to catalytically convert endogenous hydrogen peroxide into hydroxyl radicals, the most reactive oxygen species found in biology, for efficient cancer therapy. However, Fenton reaction efficiency in tumor tissue is typically limited due to restrictive conditions. One strategy to overcome this obstacle is to increase the temperature specifically at the tumor site. Herein, a tumor-targeting iron sponge (TTIS) nanocomposite based on graphdiyne oxide, which has a high affinity for iron is described. TTIS can accumulate in tumor tissue by decoration with a tumor-targeting polymer to enable tumor photoacoustic and magnetic resonance imaging. With its excellent photothermal conversion efficiency (37.5%), TTIS is an efficient photothermal therapy (PTT) agent. Moreover, the heat produced in the process of PTT can accelerate the release of iron ions from TTIS and simultaneously enhance the efficiency of the Fenton reaction, thus achieving a combined PTT and Fenton reaction-mediated cancer therapy. This work introduces a graphdiyne oxide-based iron sponge that exerts an enhanced antitumor effect through PTT and Fenton chemistry.
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